Relationship between optic disc hemorrhage and corneal hysteresis.

Abstract

OBJECTIVE:

To determine the relationship between optic disc hemorrhage (DH) and corneal hysteresis (CH).

METHODS:

Consecutive patients with prior or current photographic evidence of unilateral DH who had undergone CH measurement with the Ocular Response Analyzer (ORA; Reichert, Buffalo, NY) were enrolled. Eyes with a history of corneal disease, refractive surgery, or bilateral DH were excluded. Central corneal thickness (CCT), visual field data, 5 consecutive previous intraocular pressures (IOPs), and maximum documented peak IOP were obtained by chart review. Vertical cup-to-disc ratio (VCDR), the presence of neuroretinal rim notching, number of clock hours of beta zone parapapillary atrophy (ßPPA), and eye with greater ßPPA width were determined from photographs by 2 masked expert examiners.

RESULTS:

We identified and analyzed 49 patients with photographically documented unilateral DH. Compared to fellow non-DH eyes, eyes with DH had lower CH (8.7 ± 1.9 vs 9.2 ± 1.7; p = 0.002), higher IOP (15.6 ± 3.6 vs 14.3 ± 4.1; p = 0.017), and greater VCDR (0.79 ± 0.13 vs 0.68 ± 0.23; p < 0.001), but were similar with respect to CCT, ßPPA extent, rim notching, peak IOP, and visual field damage (all p > 0.05). Using multivariate conditional logistic regression analysis, only CH (p = 0.012) and VCDR (p = 0.004) predicted the laterality of the DH.

CONCLUSIONS:

Lower CH and greater VCDR are independently associated with DH. This suggests that CH may be a structural biomarker for an abnormality of the optic nerve complex that may be associated with progressive glaucoma. Eyes in which DH were detected had lower CH.

• Authors: Nathan M Radcliffe, Nathaniel Tracer, Carlos Gustavo V De Moraes, Celso Tello, Jeffrey M Liebmann, Robert Ritch
• Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie (Can J Ophthalmol) Vol. 55 Issue 3 Pg. 239-244 (06 2020) ISSN: 1715-3360 [Electronic] England
• PMID: 31879066 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

Topics

• Cornea
• Glaucoma
• Humans
• Intraocular Pressure
• Optic Disk
• Optic Nerve Diseases
• Retinal Hemorrhage
• Tonometry, Ocular