Naphtho-Gamma-Pyrones Produced by Aspergillus tubingensis G131: New Source of Natural Nontoxic Antioxidants.

Abstract

Seven naphtho-gamma-pyrones (NγPs), including asperpyrone E, aurasperone A, dianhydroaurasperone C, fonsecin, fonsecinone A, fonsecin B, and ustilaginoidin A, were isolated from Aspergillus tubingensis G131, a non-toxigenic strain. The radical scavenging activity of these NγPs was evaluated using ABTS assay. The Trolox equivalent antioxidant capacity on the seven isolated NγPs ranged from 2.4 to 14.6 μmol L-1. The toxicity and ability of the NγPs to prevent H2O2-mediated cell death were evaluated using normal/not cancerous cells (CHO cells). This cell-based assay showed that NγPs: (1) Are not toxic or weakly toxic towards cells and (2) are able to protect cells from oxidant injuries with an IC50 on H2O2-mediated cell death ranging from 2.25 to 1800 μmol mL-1. Our data show that A. tubingensis G131 strain is able to produce various NγPs possessing strong antioxidant activities and low toxicities, making this strain a good candidate for antioxidant applications in food and cosmetic industries.

• Authors: Quentin Carboué, Marc Maresca, Gaëtan Herbette, Sevastianos Roussos, Rayhane Hamrouni, Isabelle Bombarda
• Journal: Biomolecules (Biomolecules) Vol. 10 Issue 1 (12 24 2019) ISSN: 2218-273X [Electronic] Switzerland
• PMID: 31878243 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Benzothiazoles
• Naphthalenes
• Pyrones
• Sulfonic Acids
• 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
• Hydrogen Peroxide

Topics

• Animals
• Antioxidants (chemistry, metabolism, pharmacology)
• Aspergillus (metabolism)
• Benzothiazoles (chemistry)
• CHO Cells
• Cell Death (drug effects)
• Cricetulus
• Hydrogen Peroxide (pharmacology)
• Naphthalenes (chemistry, metabolism, pharmacology)
• Pyrones (chemistry)
• Sulfonic Acids (chemistry)