Abstract |
As we identify the loci involved in late onset neurodegenerative disease, we are finding that the majority of them are involved in damage response processes. In this short review, I propose that it is partly a failure in these damage response processes which underlie late onset disease and that the resultant pathology is a marker of the type of damage response which has failed: microglial clearance of damaged neuronal membranes in Alzheimer's disease (AD), ubiquitin proteasome clearance in the tauopathies, and lysosomal clearance in Parkinson's disease (PD). In this review, I outline this relationship. This article is not intended as a comprehensive review of the cell biology of any of these disorders but rather a summary of the evidence that the genetics and pathology of these disorders appear to point, in each case, to the removal of misfolded proteins as a critical process in disease pathogenesis.
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Authors | John Hardy |
Journal | Frontiers in neuroscience
(Front Neurosci)
Vol. 13
Pg. 1304
( 2019)
ISSN: 1662-4548 [Print] Switzerland |
PMID | 31866813
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Hardy. |