[Potential of peptidergic nootropic therapy in developmental dysphasia in children].

Abstract

AIM:

To study the therapeutic efficacy of peptidergic nootropic medication Cortexin during two-month follow-up in children with developmental dysphasia aged 3-4 years.

MATERIAL AND METHODS:

Fifty-four children with developmental dysphasia were randomized into two equal groups. The cortexin group received the drug once daily intramuscularly during 10 days. After this course, children did not receive any pharmacotherapy and were examined two months after the beginning of treatment. The control group did not receive pharmacotherapy and was examined twice in two months interval. All the parents were provided with recommendations for the stimulation of speech development in dysphasic children. Before treatment and two months later, speech development was assessed by special scales and questionnaires for parents.

RESULTS AND CONCLUSION:

After treatment with Cortexin, a significant improvement was achieved not only on the 'expressive language' scale but also on the 'attention to speech' and 'impressive language' scales. The volume of active vocabulary was increased by 2.3 times, the number of articulated phrases by 3.6 times. The evaluation of parents' questionnaires demonstrated the decrease of cerebrasthenic, psychosomatic problems, motor clumsiness, hyperactivity, attention deficit and problems with emotional control in children. The therapy contributed to the reduction of difficulties in communication and social adaptation. The positive effect of Cortexin was observed after the completion of treatment (the protracted effect).

• Authors: N N Zavadenko, L A Davydova, N Yu Suvorinova, G Sh Khondkaryan
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 119 Issue 11 Pg. 47-53 ( 2019) ISSN: 1997-7298 [Print] Russia (Federation)
• Vernacular Title: Vozmozhnosti peptidergicheskoĭ nootropnoĭ terapii pri disfazii razvitiia u deteĭ.
• PMID: 31851172 (Publication Type: Journal Article)

Chemical References

• Nootropic Agents

Topics

• Aphasia (complications, drug therapy)
• Attention Deficit Disorder with Hyperactivity (complications)
• Child
• Child, Preschool
• Humans
• Language Development Disorders (complications, drug therapy)
• Nootropic Agents (therapeutic use)
• Parents
• Speech