Abstract | BACKGROUND: PURPOSE: METHODS: RESULTS:
Salvianolic acid B significantly decreased the expressions of TXB2 and ET-1 and increased the expression of 6-keto-PGF1α in plasma, and significantly inhibited the overexpression of TNF-α and iNOS in the femoral artery walls of TAO rats at medium and high doses. CONCLUSION:
Salvianolic acid B has a protective effect on TAO rats. The mechanism may involve inhibition of thrombosis and TAO-associated inflammatory responses, which may explain the success of RSMA treatment of TAO in humans in traditional Chinese medical practice. Hence, it may be a potential drug for TAO treatment in conventional medicine.
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Authors | Ziru Zhang, Jianbo Ji, Dawei Zhang, Maoqiang Ma, Longru Sun |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 66
Pg. 153110
(Jan 2020)
ISSN: 1618-095X [Electronic] Germany |
PMID | 31790900
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Elsevier GmbH. All rights reserved. |
Chemical References |
- Benzofurans
- Lauric Acids
- lauric acid
- salvianolic acid B
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Topics |
- Animals
- Benzofurans
(chemistry, pharmacology)
- Humans
- Inflammation
(prevention & control)
- Lauric Acids
(adverse effects)
- Male
- Medicine, Chinese Traditional
- Plant Roots
(chemistry)
- Rats
- Rats, Wistar
- Salvia miltiorrhiza
(chemistry)
- Thromboangiitis Obliterans
(chemically induced, drug therapy)
- Thrombosis
(prevention & control)
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