Abstract |
Microparticle (MP)-associated tissue factor (TF) activity in plasma might play a role in human disseminated intravascular coagulation ( DIC). The aim of this study was to compare MP-TF activity between non- DIC and DIC groups. Ten clinically healthy beagles and 26 diseased dogs were enrolled. The proportion of dogs with increased MP-TF activity was significantly higher in the DIC group than the non- DIC group (P=0.014). MP-TF activity in the DIC group was significantly higher than the non- DIC group (P=0.021). MP-TF activity positively correlated with plasma D-dimer concentration (r=0.42, P=0.034). Moreover, MP-TF activity was decreased by the time of recovery in some dogs with DIC. Larger prospective studies are warranted to assess its value as a diagnostic and prognostic biomarker in DIC.
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Authors | Kosuke Kobayashi, Kenji Baba, Masaya Igase, Takako Shimokawa Miyama, Satoshi Kambayashi, Masaru Okuda |
Journal | The Journal of veterinary medical science
(J Vet Med Sci)
Vol. 82
Issue 1
Pg. 56-60
(Jan 17 2020)
ISSN: 1347-7439 [Electronic] Japan |
PMID | 31787663
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Cell-Derived Microparticles
(metabolism)
- Disseminated Intravascular Coagulation
(blood, metabolism, veterinary)
- Dog Diseases
(blood, metabolism)
- Dogs
- Female
- Male
- Retrospective Studies
- Thromboplastin
(metabolism)
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