Skin blood flow response to topically applied methyl nicotinate: Possible mechanisms.

Abstract

BACKGROUND:

Methyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be valuable as a local provocation in the assessment of microcirculation and skin viability. The mechanisms through which MN mediates its vascular effect are not fully known. The aim of this study was to characterize the vasodilatory effects of topically applied MN and to study the involvement of nitric oxide (NO), local sensory nerves, and prostaglandin-mediated pathways.

METHODS:

MN was applied on the skin of healthy subjects in which NO-mediated (L-NMMA), nerve-mediated (lidocaine/prilocaine), and cyclooxygenase-mediated (NSAID) pathways were selectively inhibited. Microvascular responses in the skin were measured using laser speckle contrast imaging (LSCI).

RESULTS:

NSAID reduced the MN-induced perfusion increase with 82% (P < .01), whereas lidocaine/prilocaine reduced it with 32% (P < .01). L-NMMA did not affect the microvascular response to MN.

CONCLUSION:

The prostaglandin pathway and local sensory nerves are involved in the vasodilatory actions of MN in the skin.

• Authors: Sherif Elawa, Robin Mirdell, Simon Farnebo, Erik Tesselaar
• Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (Skin Res Technol) Vol. 26 Issue 3 Pg. 343-348 (May 2020) ISSN: 1600-0846 [Electronic] England
• PMID: 31777124 (Publication Type: Journal Article)
• Copyright: © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Nicotinic Acids
• Prostaglandins
• Vitamin B Complex
• methyl nicotinate
• Nitric Oxide Synthase

Topics

• Administration, Topical
• Adult
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, pharmacology)
• Case-Control Studies
• Female
• Humans
• Iontophoresis (instrumentation)
• Male
• Microcirculation (drug effects)
• Neurons, Afferent (drug effects)
• Nicotinic Acids (administration & dosage, pharmacology)
• Nitric Oxide Synthase (drug effects)
• Prostaglandins (pharmacology)
• Regional Blood Flow (drug effects)
• Skin (blood supply, drug effects, innervation)
• Tissue Survival (drug effects, radiation effects)
• Vasodilation (drug effects, physiology)
• Vitamin B Complex (administration & dosage, pharmacology)