Abstract |
Thyroid dysfunction (TD) is caused by thyroid peroxidase (TPO) antibody, as seen in Hashimoto's disease. TD is a common problem of reproductive age and may impair fetal development. Here, we determined the effect of TPO antibody on perinatal outcomes in Japanese women with TD before conception. A retrospective study involving cases of maternal TD with term singleton birth was conducted. The subjects with TD were divided into two groups according to the presence (n = 22) or absence (n = 20) of TPO antibody. The control groups matched for age, parity, and gestational weeks were selected for TPO antibody-positive (n = 44) and -negative TD subjects (n = 40), respectively. Using the standard curve of Japanese placental weight, the frequency of placental weight less than the 50th percentile (small placenta) was examined. Placental weight was lower among TPO antibody-positive TD subjects, compared with TPO antibody-negative TD subjects (p < 0.01). However, other outcomes were similar between the groups. Importantly, compared with control mothers, placental weight was significantly lower (p < 0.01), birth weight tended to be lower (p = 0.07), and the incidence of gestational diabetes mellitus was higher (p = 0.02) among TPO antibody-positive subjects. There was no significant difference in placental weight between TPO antibody-negative subjects and controls. The frequency of small placenta was significantly higher in TPO antibody-positive subjects (odds ratio: 16.7) even when considering diabetes and pregnancy induced hypertension. Thus, the presence of TPO antibody is associated with lower placental weight among Japanese women having TD.
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Authors | Junko Ushijima, Seishi Furukawa, Hiroshi Sameshima |
Journal | The Tohoku journal of experimental medicine
(Tohoku J Exp Med)
Vol. 249
Issue 3
Pg. 231-236
(11 2019)
ISSN: 1349-3329 [Electronic] Japan |
PMID | 31776300
(Publication Type: Journal Article)
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Chemical References |
- Antibodies
- Autoantigens
- Iron-Binding Proteins
- TPO protein, human
- Iodide Peroxidase
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Topics |
- Adult
- Antibodies
(blood)
- Autoantigens
(immunology)
- Female
- Humans
- Iodide Peroxidase
(immunology)
- Iron-Binding Proteins
(immunology)
- Organ Size
- Placenta
(pathology)
- Pregnancy
- Pregnancy Outcome
- Thyroid Gland
(physiopathology)
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