Moderate Frequency of Anti-Thyroglobulin Antibodies in the Early Phase of Subacute Thyroiditis.

Abstract

BACKGROUND:

Subacute thyroiditis is generally believed to be induced by viral infection, and little attention has been paid to anti-thyroid antibodies.

OBJECTIVES:

Our study aimed to assess the prevalence of anti-thyroid antibodies in patients with subacute thyroiditis.

METHODS:

Anti-thyroglobulin (TgAb) and anti-thyroid peroxidase antibodies (TPOAb) were measured with 4 different immunoassay kits currently used in 40 patients in the early phase of subacute thyroiditis.

RESULTS:

The proportion of samples positive for TgAb was 52.5 ± 13.7% (mean of 4 kits), which was significantly (p < 0.05) higher than that positive for TPOAb (15.6 ± 6.5%). The prevalence of positive TgAb alone (negative TPOAb) was also significantly higher than that of TPOAb alone (negative TgAb). TgAb titers decreased or disappeared within 4 months to 6 years in 6 patients.

CONCLUSIONS:

Patient samples were moderately positive for TgAb initially, but the titer decreased or disappeared afterwards in subacute thyroiditis.

• Authors: Eijun Nishihara, Nobuyuki Amino, Takumi Kudo, Kazuyoshi Kohsaka, Mitsuru Ito, Shuji Fukata, Mitsushige Nishikawa, Hirotoshi Nakamura, Akira Miyauchi
• Journal: European thyroid journal (Eur Thyroid J) Vol. 8 Issue 5 Pg. 268-272 (Oct 2019) ISSN: 2235-0640 [Print] England
• PMID: 31768338 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 by S. Karger AG, Basel.