Pooled Dosing and Efficacy Analysis of the Sufentanil Sublingual Tablet 30 mcg Across Demographic Subgroups for the Management of Moderate-to-Severe Acute Pain.

Abstract

PURPOSE:

To aid nurses in dosing sufentanil sublingual tablet (SST) 30 mcg administered via a single-dose applicator, dosing requirements and efficacy of SST 30 mcg were analyzed across age, sex, race, and body mass index subgroups.

DESIGN:

Patient characteristics were pooled from three postoperative studies (two placebo-controlled and one open-label) and one open-label emergency department study. Drug dosing and efficacy data were pooled from the postoperative studies.

METHODS:

Efficacy was assessed through summed pain intensity difference to baseline during 12 hours across subgroups.

FINDINGS:

Mean (standard deviation) drug doses administered from 0 to 12 hours was 3.9 (2.0) for SST 30 mcg and was less frequent for older (≥65 years) versus younger patients. The summed pain intensity difference to baseline during 12 hours was superior with SST 30 mcg versus placebo across all subgroups.

CONCLUSIONS:

SST 30 mcg is a sublingual opioid analgesic with efficacy across demographic subgroups.

• Authors: Jacob L Hutchins, David Leiman, Zubaid Rafique, Karen P DiDonato, Pamela P Palmer
• Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses (J Perianesth Nurs) Vol. 35 Issue 1 Pg. 22-28 (Feb 2020) ISSN: 1532-8473 [Electronic] United States
• PMID: 31732448 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Chemical References

• Analgesics, Opioid
• Sufentanil

Topics

• Acute Pain (drug therapy)
• Administration, Sublingual
• Adult
• Analgesics, Opioid (administration & dosage, therapeutic use)
• Female
• Humans
• Male
• Medication Systems, Hospital (standards, statistics & numerical data)
• Middle Aged
• Pain Management (methods, standards, statistics & numerical data)
• Pain Measurement (methods)
• Sufentanil (administration & dosage, therapeutic use)