High-dose Propofol Anesthesia Reduces the Occurrence of Postoperative Cognitive Dysfunction via Maintaining Cytoskeleton.

Abstract

Postoperative cognitive dysfunction (POCD) is a common postoperative complication observed in patients following. Here we tested the molecular mechanisms of memory loss in hippocampus of rat POCD model. We found that high-dose propofol anesthesia significantly alleviated spatial memory loss. The proteomes and transcriptomes in hippocampus showed that hippocampal cytoskeleton related pathways were abnormal in low group while not in high group. The protein assays confirmed that hippocampal actin cytoskeleton was depolymerized in low group while maintained in high group. This study confirms that high-dose propofol anesthesia could mitigate the development of POCD and provides evidences for actin cytoskeleton associated with this syndrome.

• Authors: Jun Ma, John Williams, Derek Eastwood, Siyu Lin, Xiaoyan Qian, Qiwu Fang, Doris Cope, Zengqiang Yuan, Liu Cao, Jianxiong An
• Journal: Neuroscience (Neuroscience) Vol. 421 Pg. 136-143 (11 21 2019) ISSN: 1873-7544 [Electronic] United States
• PMID: 31682819 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019. Published by Elsevier Ltd.

Chemical References

• Anesthetics, Intravenous
• Proteome
• Propofol

Topics

• Anesthesia (adverse effects)
• Anesthetics, Intravenous (administration & dosage, adverse effects)
• Animals
• Cytoskeleton (drug effects)
• Hippocampus (metabolism)
• Male
• Maze Learning (drug effects)
• Memory Disorders (chemically induced)
• Postoperative Cognitive Complications (chemically induced, psychology)
• Propofol (administration & dosage, adverse effects)
• Proteome
• Rats
• Rats, Sprague-Dawley
• Transcriptome