Current scenario of ferrocene-containing hybrids for antimalarial activity.

Abstract

Hybrid molecules have the potential to enhance the efficacy against both drug-sensitive and drug-resistant organisms, and Ferroquine, a ferrocene hybrid, has demonstrated great potency in clinical trials against both drug-sensitive and drug-resistant malaria. Accordingly, hybridization of ferrocene with other antimalarial pharmacophores represents a promising strategy to develop novel antimalarial candidates. This work attempts to systematically review the recent study of ferrocene hybrids in the design and development of antimalarial agents, and the structure-activity relationship (SAR) is also discussed to provide an insight for rational design of more effective antibacterial candidates.

• Authors: Jiaqi Xiao, Zhou Sun, Fangong Kong, Feng Gao
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 185 Pg. 111791 (Jan 01 2020) ISSN: 1768-3254 [Electronic] France
• PMID: 31669852 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2019 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antimalarials
• Artemisinins
• Ferrous Compounds
• Metallocenes
• Peroxides
• Quinolines
• artemisinin
• quinoline
• ferrocene

Topics

• Antimalarials (chemistry, pharmacology)
• Artemisinins (chemistry, pharmacology)
• Ferrous Compounds (chemistry, pharmacology)
• Humans
• Malaria (drug therapy)
• Metallocenes (chemistry, pharmacology)
• Molecular Structure
• Parasitic Sensitivity Tests
• Peroxides (chemistry, pharmacology)
• Plasmodium falciparum (drug effects)
• Quinolines (chemistry, pharmacology)