Abstract | PURPOSE: METHODS: In this randomized control trial, a total of 164 consecutive patients were enrolled. By double-blinded randomization protocol, patients were allocated into hemithyroidectomy with pCND (n = 82) or without pCND (n = 82). With intention-to-treat analysis, post-surgical pathological and clinical course, surgery-related complications, causes and clinical course of protocol-violated cases and 5-year recurrence-free survival were compared. RESULTS: Operation time, hospital stay, and post-surgical complication were not significantly different between the two groups. In the pCND (+) group, occult lymph node metastasis rate was 50.0%, and lymph node ratio (metastatic/harvested lymph nodes) was 45.2%. Ten patients in the pCND (+) group had converted to undergo onsite or staged completion total thyroidectomy due to the presence of metastatic central lymph nodes and/or positive resection margin. Until last follow-up (mean 73.4 months), one regional recurrence developed in the pCND (-) group, and three regional recurrences occurred in the pCND (+) group. Five-year recurrence-free survival was similar between the two groups. CONCLUSION: Although ipsilateral pCND could clear occult lymph node metastasis in the central compartment, it failed to provide any oncological benefit for cN0 PTMC patients.
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Authors | Bo Young Kim, Nayeon Choi, Sun Wook Kim, Han-Sin Jeong, Man Ki Chung, Young- Ik Son |
Journal | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
(Eur Arch Otorhinolaryngol)
Vol. 277
Issue 2
Pg. 569-576
(Feb 2020)
ISSN: 1434-4726 [Electronic] Germany |
PMID | 31664515
(Publication Type: Journal Article, Randomized Controlled Trial)
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Topics |
- Adult
- Carcinoma, Papillary
(pathology, surgery)
- Double-Blind Method
- Female
- Humans
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
(pathology)
- Male
- Middle Aged
- Neck Dissection
(methods)
- Prospective Studies
- Thyroid Neoplasms
(pathology, surgery)
- Thyroidectomy
(methods)
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