HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Source apportionment of primary and secondary PM2.5: Associations with pediatric respiratory disease emergency department visits in the U.S. State of Georgia.

Abstract
We developed a hybrid chemical transport model and receptor model (CTM-RM) to conduct source apportionment of both primary and secondary PM2.5 (particulate matter ≤2.5 μm in diameter) at 36 km resolution throughout the U.S. State of Georgia for the years 2005 and 2007. This novel source apportionment model enabled us to estimate and compare associations of short-term changes in 12 PM2.5 source concentrations (agriculture, biogenic, coal, dust, fuel oil, metals, natural gas, non-road mobile diesel, non-road mobile gasoline, on-road mobile diesel, on-road mobile gasoline, and all other sources) with emergency department (ED) visits for pediatric respiratory diseases. ED visits for asthma (N = 49,651), pneumonia (N = 25,558), and acute upper respiratory infections (acute URI, N = 235,343) among patients aged ≤18 years were obtained from patient claims records. Using a case-crossover study, we estimated odds ratios per interquartile range (IQR) increase for 3-day moving average PM2.5 source concentrations using conditional logistic regression, matching on day-of-week, month, and year, and adjusting for average temperature, humidity, and holidays. We fit both single-source and multi-source models. We observed positive associations between several PM2.5 sources and ED visits for asthma, pneumonia, and acute URI. For example, for asthma, per IQR increase in the source contribution in the single-source model, odds ratios were 1.022 (95% CI: 1.013, 1.031) for dust; 1.050 (95% CI: 1.036, 1.063) for metals, and 1.091 (95% CI: 1.064, 1.119) for natural gas. These sources comprised 5.7%, 2.2%, and 6.3% of total PM2.5 mass, respectively. PM2.5 from metals and natural gas were positively associated with all three respiratory outcomes. In addition, non-road mobile diesel was positively associated with pneumonia and acute URI.
AuthorsMengjiao Huang, Cesunica Ivey, Yongtao Hu, Heather A Holmes, Matthew J Strickland
JournalEnvironment international (Environ Int) Vol. 133 Issue Pt A Pg. 105167 (12 2019) ISSN: 1873-6750 [Electronic] Netherlands
PMID31634664 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
CopyrightCopyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
Chemical References
  • Air Pollutants
  • Coal
  • Dust
  • Gasoline
  • Particulate Matter
Topics
  • Adolescent
  • Air Pollutants (analysis, toxicity)
  • Child
  • Coal
  • Cross-Over Studies
  • Dust
  • Emergency Service, Hospital (statistics & numerical data)
  • Female
  • Gasoline
  • Georgia
  • Humans
  • Logistic Models
  • Male
  • Odds Ratio
  • Particulate Matter (analysis, toxicity)
  • Respiration Disorders (etiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: