Antibiotic sensitivity and clinical outcomes in staphylococcal scalded skin syndrome.

Abstract

Staphylococcal scalded skin syndrome causes widespread skin denudation primarily in infants < 1 year old. Selection of empiric therapy is complicated by rising rates of antibiotic resistance in community-acquired staphylococcal infections. Consistent with a previous study, this retrospective review found that SSSS-associated isolates were more likely to be clindamycin-resistant and less likely to be methicillin-resistant compared to overall staphylococcal infections. We favor cephalosporins and penicillinase-resistant penicillins (eg, oxacillin) for empiric management of SSSS, with consideration of adding MRSA coverage in communities with high MRSA prevalence or failure to improve following several days of treatment.

• Authors: Zixiao Wang, Jessica L Feig, Diana B Mannschreck, Bernard A Cohen
• Journal: Pediatric dermatology (Pediatr Dermatol) Vol. 37 Issue 1 Pg. 222-223 (Jan 2020) ISSN: 1525-1470 [Electronic] United States
• PMID: 31626359 (Publication Type: Journal Article)
• Copyright: © 2019 Wiley Periodicals, Inc.

Chemical References

• Anti-Bacterial Agents
• Clindamycin

Topics

• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Clindamycin (pharmacology, therapeutic use)
• Drug Resistance, Bacterial
• Female
• Humans
• Infant
• Infant, Newborn
• Male
• Methicillin Resistance
• Microbial Sensitivity Tests
• Penicillin Resistance
• Retrospective Studies
• Sensitivity and Specificity
• Staphylococcal Scalded Skin Syndrome (drug therapy, microbiology)
• Staphylococcus aureus (drug effects, isolation & purification)