GM-CSF in inflammation.

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) has many more functions than its original in vitro identification as an inducer of granulocyte and macrophage development from progenitor cells. Key features of GM-CSF biology need to be defined better, such as the responding and producing cell types, its links with other mediators, its prosurvival versus activation/differentiation functions, and when it is relevant in pathology. Significant preclinical data have emerged from GM-CSF deletion/depletion approaches indicating that GM-CSF is a potential target in many inflammatory/autoimmune conditions. Clinical trials targeting GM-CSF or its receptor have shown encouraging efficacy and safety profiles, particularly in rheumatoid arthritis. This review provides an update on the above topics and current issues/questions surrounding GM-CSF biology.

• Authors: John A Hamilton
• Journal: The Journal of experimental medicine (J Exp Med) Vol. 217 Issue 1 (01 06 2020) ISSN: 1540-9538 [Electronic] United States
• PMID: 31611249 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2019 Hamilton.

Chemical References

• Granulocyte-Macrophage Colony-Stimulating Factor

Topics

• Animals
• Arthritis, Rheumatoid (immunology)
• Cell Differentiation (immunology)
• Granulocyte-Macrophage Colony-Stimulating Factor (immunology)
• Granulocytes (immunology)
• Humans
• Inflammation (immunology)
• Macrophages (immunology)