Evaluation of the additional effect of topical 5-fluorouracil to needling in the treatment of localized vitiligo.

Abstract

BACKGROUND:

Microneedling is a valuable tool that can be used in transdermal drug delivery in vitiligo patients to improve drug permeability and efficacy with minor side effects.

AIMS:

The aim of this study is to assess the effectiveness of using microneedling prior to application of topical 5-FU in treatment of localized vitiligo and to compare its results with microneedling alone.

METHODS:

Twenty-seven patients with localized stable vitiligo are chosen. Two patches are determined in every patient: patch A treated with needling alone and patch B treated with needling followed by topical application of 5-fluorouracil once every 2 weeks for three months. Repigmentation was accessed by grades ranging from G0; no response to G4; >75% repigmentation. Side effects were reported in every visit.

RESULTS:

Microneedling followed by topical application of 5-fluorouracil showed better response than needling alone with minimal side effects.

CONCLUSION:

Combining microneedling with topical drug application yields better results in treating localized vitiligo.

• Authors: Enayat Mohamed Attwa, Shrook A Khashaba, Nehal Anwar Ezzat
• Journal: Journal of cosmetic dermatology (J Cosmet Dermatol) Vol. 19 Issue 6 Pg. 1473-1478 (Jun 2020) ISSN: 1473-2165 [Electronic] England
• PMID: 31524967 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
• Copyright: © 2019 Wiley Periodicals, Inc.

Chemical References

• Fluorouracil

Topics

• Administration, Cutaneous
• Adolescent
• Adult
• Aged
• Child
• Combined Modality Therapy (methods)
• Dry Needling (methods)
• Female
• Fluorouracil (administration & dosage)
• Humans
• Male
• Middle Aged
• Skin Pigmentation (drug effects)
• Treatment Outcome
• Vitiligo (diagnosis, therapy)
• Young Adult