Fixed-jaw technique to improve IMRT plan quality for the treatment of cervical and upper thoracic esophageal cancer.

Abstract

The purpose of this study was to investigate the potential advantages of the fixed-jaw technique (FJT) over the conventional split-field technique (SFT) for cervical and upper thoracic esophageal cancer (EC) patients treated with intensity-modulated radiotherapy. The SFT and FJT plans were generated for 15 patients with cervical and upper thoracic EC. Dosimetric parameters and delivery efficiency were compared. An area ratio (AR) of the jaw opening to multileaf collimator (MLC) aperture weighted by the number of monitor units (MUs) was defined to evaluate the impact of the transmission through the MLC on the dose gradient outside the PTV50.4, and the correlation between the gradient index (GI) and AR was analyzed. The FJT plans achieved a better GI and AR (P < 0.001). There was a positive correlation between the GI and AR in the FJT (r = 0.883, P < 0.001) and SFT plans (r = 0.836, P < 0.001), respectively. Moreover, the mean dose (Dmean ), V5Gy -V40Gy for the lungs and the Dmean , V5Gy -V50Gy for the body-PTV50.4 in the FJT plans were lower than those in the SFT plans (P < 0.05). The FJT plans demonstrated a reduction trend in the doses to the spinal cord PRV and heart, but only the difference in the heart Dmean reached statistical significance (P < 0.05). The FJT plans reduced the number of MUs and subfields by 5.5% and 17.9% and slightly shortened the delivery time by 0.23 min (P < 0.05). The gamma-index passing rates were above 95% for both plans. The FJT combined with target splitting can provide superior organs at risk sparing and similar target coverage without compromising delivery efficiency and should be a preferred intensity-modulated radiotherapy planning method for cervical and upper thoracic EC patients.

• Authors: Wei Song, Hong Lu, Jie Liu, Di Zhao, Jun Ma, Biyun Zhang, Dahai Yu, Xinchen Sun, Jinkai Li
• Journal: Journal of applied clinical medical physics (J Appl Clin Med Phys) Vol. 20 Issue 10 Pg. 24-32 (Oct 2019) ISSN: 1526-9914 [Electronic] United States
• PMID: 31460704 (Publication Type: Journal Article)
• Copyright: © 2019 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

Topics

• Aged
• Algorithms
• Esophageal Neoplasms (radiotherapy)
• Humans
• Jaw (physiology, radiation effects)
• Jaw Relation Record
• Middle Aged
• Organs at Risk (radiation effects)
• Prognosis
• Quality Improvement
• Radiotherapy Dosage
• Radiotherapy Planning, Computer-Assisted (methods)
• Radiotherapy, Intensity-Modulated (methods, standards)
• Thoracic Neoplasms (radiotherapy)