A descriptive follow-up interview study assessing patient-centred outcomes: Salford Lung Study in Asthma (SLS Asthma).

Abstract

The Salford Lung Study in Asthma (SLS Asthma) was a multicentre, randomised, controlled, open-label trial that assessed initiating once-daily, single-inhaler fluticasone furoate/vilanterol (FF/VI) 100 μg/25 μg or 200 μg/25 μg versus continuing usual care. A subgroup (n = 400) from SLS Asthma was enrolled in this exploratory, interview-based follow-up study. Quantitative and qualitative data were collected via questionnaires. The primary objective was to capture patient-centred outcomes (symptom experience, quality of life [QoL], disease management behaviours) and patient experience. Secondary objectives were to assess the correlation of patient-reported outcomes with pre-defined variables from SLS Asthma (Asthma Control Test [ACT] score). The follow-up sample was representative of the SLS Asthma population; half reported asthma improvement during the study. Breathlessness was the most likely symptom to improve (47.8% of patients reported improvement). Most patients reported 'no change' in overall QoL (57.5%) and daily life domains (functioning 66.3%, activities 68.3%, relationships 86.8%, psychological 68.5%). Functioning was reported as the most frequently improved domain (29.8% of patients). Perceived improvement in asthma control (42.5%) and confidence (37.3%) was frequent. ACT responders (defined as patients achieving an ACT score ≥20 and/or an increase of ≥3 in ACT score from baseline at Week 52) were more likely to report asthma improvement (88.7% of patients reporting 'a lot' of improvement) than non-responders. Patients' asthma experiences generally improved during SLS Asthma. Clinical improvements were often associated with perceived improvement by patients, particularly among ACT responders.

• Authors: Lynda Doward, Henrik Svedsater, Diane Whalley, Rebecca Crawford, David Leather, James Lay-Flurrie, Nick Bosanquet
• Journal: NPJ primary care respiratory medicine (NPJ Prim Care Respir Med) Vol. 29 Issue 1 Pg. 31 (08 15 2019) ISSN: 2055-1010 [Electronic] England
• PMID: 31417102 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Androstadienes
• Benzyl Alcohols
• Chlorobenzenes
• vilanterol
• fluticasone furoate

Topics

• Administration, Inhalation
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Androstadienes (administration & dosage)
• Asthma (drug therapy, psychology)
• Benzyl Alcohols (administration & dosage)
• Chlorobenzenes (administration & dosage)
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Patient-Centered Care (methods)
• Quality of Life
• Treatment Outcome
• Young Adult