Abstract | BACKGROUND: METHODS: Patients were randomly allocated to receive dexmedetomidine (n = 63) (loading dose, 1 μg/kg for 10 minutes and continuous infusion, 0.4 μg/kg/hr) or normal saline (n = 63). The ONSD was measured at 10 minutes after induction of anesthesia in the supine position (T1), 30 minutes (T2) and 60 minutes (T3) after establishment of pneumoperitoneum in the steep Trendelenburg position, and at closing the skin in the supine position (T4). Hemodynamic and respiratory variables were measured at every time point. RESULTS: ONSDs at T2, T3, and T4 were significantly smaller in the dexmedetomidine group than in the control group (5.26 ± 0.25 mm vs 5.71 ± 0.26 mm, 5.29 ± 0.24 mm vs 5.81 ± 0.23 mm, and 4.97 ± 0.24 mm vs 5.15 ± 0.28 mm, all P <.001). ONSDs at T2, T3, and T4 were significantly increased compared to T1 in both groups. Hemodynamic and respiratory variables, except heart rate, did not significantly differ between the 2 groups. The bradycardia and atropine administration were not significantly different between the 2 groups. CONCLUSION:
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Authors | Jihion Yu, Jun-Young Park, Doo-Hwan Kim, Gi-Ho Koh, Wonyeong Jeong, Eunkyul Kim, Jun Hyuk Hong, Jai-Hyun Hwang, Young-Kug Kim |
Journal | Medicine
(Medicine (Baltimore))
Vol. 98
Issue 33
Pg. e16772
(Aug 2019)
ISSN: 1536-5964 [Electronic] United States |
PMID | 31415378
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenergic alpha-2 Receptor Agonists
- Dexmedetomidine
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Topics |
- Adrenergic alpha-2 Receptor Agonists
(administration & dosage, pharmacology)
- Aged
- Dexmedetomidine
(administration & dosage, pharmacology)
- Double-Blind Method
- Head-Down Tilt
- Humans
- Intracranial Hypertension
(prevention & control)
- Intracranial Pressure
(drug effects)
- Intraoperative Period
- Laparoscopy
- Male
- Optic Nerve
(diagnostic imaging, drug effects)
- Prostatectomy
- Robotic Surgical Procedures
- Treatment Outcome
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