Abstract | BACKGROUND AND PURPOSE:
Moyamoya disease (MMD) is a progressive cerebrovascular disease with unknown etiology. Growing evidence suggest its involvement of autoimmune and genetic mechanisms in the pathogenesis of MMD. This study aims to clarify the association between HLA allele and MMD. METHODS: Case-control study: the DNA of 136 MMD patients in Japan was extracted and the genotype of human leukocyte antigen (HLA) from this DNA was determined by super-high-resolution single-molecule sequence-based typing using next-generation sequencing. Next, the frequency of each HLA allele (HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1, and HLA-DPB1) was compared with those in the Japanese control database. In addition, haplotype estimation was performed using the expectation maximization algorithm. RESULTS: CONCLUSIONS:
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Authors | Ryosuke Tashiro, Kuniyasu Niizuma, Seik-Soon Khor, Katsushi Tokunaga, Miki Fujimura, Hiroyuki Sakata, Hidenori Endo, Hidetoshi Inoko, Koetsu Ogasawara, Teiji Tominaga |
Journal | PloS one
(PLoS One)
Vol. 14
Issue 8
Pg. e0220858
( 2019)
ISSN: 1932-6203 [Electronic] United States |
PMID | 31412073
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA-DRB1 Chains
- HLA-DRB1*04 antigen
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Topics |
- Adult
- Alleles
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- HLA-DRB1 Chains
(genetics)
- Humans
- Japan
- Male
- Middle Aged
- Moyamoya Disease
(genetics)
- Thyroiditis, Autoimmune
(genetics)
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