(±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp.

Abstract

Two new dimeric compounds of the alternariol class, (±)-alternarlactones A (1) and B (2), were isolated along with 11 known compounds from the fungus Alternaria alternata P1210. Their structures were elucidated with the assistance of long-range HSQMBC to address inadequate cross-peaks in HMBC that result from the highly dense quaternary carbons, as well as theoretical calculations. All isolated altenuisol derivatives were screened for their antiparasitic activities, which provide a preliminary structure-activity relationship of this class of compounds against neglected tropical diseases.

• Authors: Yan-Ni Shi, Stefan Pusch, Yi-Ming Shi, Christian Richter, Jose G Maciá-Vicente, Harald Schwalbe, Marcel Kaiser, Till Opatz, Helge B Bode
• Journal: The Journal of organic chemistry (J Org Chem) Vol. 84 Issue 17 Pg. 11203-11209 (09 06 2019) ISSN: 1520-6904 [Electronic] United States
• PMID: 31409073 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiparasitic Agents
• Lactones
• alternariol

Topics

• Alternaria (chemistry, isolation & purification)
• Antiparasitic Agents (chemistry)
• Dimerization
• Lactones (chemistry)
• Salt-Tolerant Plants (microbiology)