IgM binding to sialosyllactosaminylparagloboside in a patient with polyradiculoneuropathy due to Mycoplasma pneumoniae infection.

Abstract

IgM in serum without paraprotein in a patient with polyradiculoneuropathy due to a Mycoplasma pneumoniae infection reacted specifically with a ganglioside, sialosyllactosaminylparagroboside (SLPG), in a human peripheral nerve on a thin-layer chromatogram plate by an immunostaining technique. This finding suggests the possibility that anti-SLPG antibody in the patient's serum may play a role in the pathogenesis of neuropathy.

• Authors: T Inuzuka, N Miyatani, H Baba, M Tanaka, K Tanaka, S Sato, K Nakamura, T Miyatake
• Journal: Acta neurologica Scandinavica (Acta Neurol Scand) Vol. 78 Issue 1 Pg. 53-7 (Jul 1988) ISSN: 0001-6314 [Print] Denmark
• PMID: 3140569 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gangliosides
• Globosides
• Glycosphingolipids
• Immunoglobulin mu-Chains
• sialosyllactosaminylparagloboside

Topics

• Female
• Gangliosides (metabolism)
• Globosides (metabolism)
• Glycosphingolipids (metabolism)
• Humans
• Immunoglobulin mu-Chains (blood)
• Middle Aged
• Pneumonia, Mycoplasma (complications)
• Polyradiculoneuropathy (etiology, immunology, microbiology)