Constituents of the Edible Leaves of Melicope pteleifolia with Potential Analgesic Activity.

Abstract

Melicope pteleifolia has long been consumed as a popular vegetable and tea in Southeast Asian countries, including Malaysia and southern mainland China, and is effective in the treatment of colds and inflammation. In the search for active metabolites that can explain its traditional use as an antipyretic, six new phloroacetophenone derivatives (3-8) along with seven known compounds (1, 2, and 9-13) were isolated from the leaves of M. pteleifolia. Their chemical structures were confirmed by extensive spectroscopic analysis including NMR, IR, ECD, and HRMS. All compounds isolated from the leaves of M. pteleifolia (1-13) have a phloroacetophenone skeleton. Notably, the new compound 8 contains an additional cyclobutane moiety in its structure. The bioactivities of the isolated compounds were evaluated, and compounds 1, 6, and 7 inhibited tumor necrosis factor-α-induced prostaglandin E2. Moreover, the major constituent, 3,5-di-C-β-d-glucopyranosyl phloroacetophenone (1), was found to be responsible for the antipyretic activity of M. pteleifolia based on in vivo experiments.

• Authors: Ba-Wool Lee, Jung-Geun Park, Thi Kim Quy Ha, Ha Thanh Tung Pham, Jin-Pyo An, Jung-Ran Noh, Chul-Ho Lee, Won-Keun Oh
• Journal: Journal of natural products (J Nat Prod) Vol. 82 Issue 8 Pg. 2201-2210 (08 23 2019) ISSN: 1520-6025 [Electronic] United States
• PMID: 31393125 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics

Topics

• Analgesics (pharmacology)
• Animals
• Cells, Cultured
• Humans
• Male
• Mice
• Mice, Inbred ICR
• Molecular Structure
• Plant Leaves (chemistry)
• Plants, Edible (chemistry)
• Rutaceae (chemistry)
• Spectrum Analysis (methods)