Dissolving Triamcinolone-Embedded Microneedles for the Treatment of Keloids: A Single-Blinded Intra-Individual Controlled Clinical Trial.

Abstract

INTRODUCTION:

Keloids are a prevalent chronic skin disorder with significant psychosocial morbidity. Intralesional corticosteroid injections are the first-line treatment but are painful and require repeated injections by medical professionals. Dissolving microneedles are a novel method of cutaneous drug delivery that induces minimal/no pain and can be self-administered. The objective of the study was to evaluate the efficacy and safety of triamcinolone-embedded dissolving microneedles in treatment of keloids.

METHODS:

This was a single-blind, intra-individual controlled two-phase clinical trial of 8-week duration each. Two keloids per subject were selected for (1) once-daily 2-min application with microneedles for 4 weeks, followed by no treatment for the next 4 weeks, or (2) non-intervention as control. Primary outcome was change in keloid volume as assessed by a high-resolution 3D scanner.

RESULTS:

There was significant reduction in keloid volume compared with controls after 4 weeks of treatment. This reduction was greater with a higher dosage of triamcinolone used.

CONCLUSIONS:

Once-daily application of dissolving triamcinolone-embedded microneedles significantly reduced the volume of keloids. The treatment was safe, can be self-administered and can serve as an alternative for patients unsuitable for conventional treatments.

TRIAL REGISTRATION:

Trial Registry: Health Science Authority (Singapore) Clinical Trials Register Registration number: 2015/00440.

• Authors: Colin W X Tan, Wei Ding Tan, Ruchir Srivastava, Ai Ping Yow, Damon W K Wong, Hong Liang Tey
• Journal: Dermatology and therapy (Dermatol Ther (Heidelb)) Vol. 9 Issue 3 Pg. 601-611 (Sep 2019) ISSN: 2193-8210 [Print] Switzerland
• PMID: 31376063 (Publication Type: Journal Article)