Tumour-promoting ability of mancozeb, a carbamate fungicide, on mouse skin.

Abstract

In this study the tumour-promoting activity of a carbamate fungicide, mancozeb, has been observed following topical application on mouse skin in a two-stage initiation--promotion protocol for carcinogenesis. Female Swiss albino mice were initiated with a single subcarcinogenic dose (52 micrograms) of 7,12-dimethylbenz[a]anthracene painted on the interscapular region. Seven days after initiation the mice underwent topical application of mancozeb (100 mg/kg body wt) three times per week as promoter. Development of tumours was observed after 12 weeks of mancozeb application in 1/14 animals and 100% tumorigenesis was recorded after 17 weeks of mancozeb application. On histological examination, these tumours were found mostly to be benign in nature, e.g. squamous cell papillomas and keratocanthomas.

• Authors: Y Shukla, M Antony, S Kumar, N K Mehrotra
• Journal: Carcinogenesis (Carcinogenesis) Vol. 9 Issue 8 Pg. 1511-2 (Aug 1988) ISSN: 0143-3334 [Print] England
• PMID: 3135958 (Publication Type: Journal Article)

Chemical References

• Fungicides, Industrial
• Thiocarbamates
• Maneb
• 9,10-Dimethyl-1,2-benzanthracene
• mancozeb
• Zineb

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Cocarcinogenesis
• Female
• Fungicides, Industrial (toxicity)
• Maneb (toxicity)
• Mice
• Skin Neoplasms (chemically induced, pathology)
• Thiocarbamates (toxicity)
• Zineb (toxicity)