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Lose the lipid: renoprotection conferred by Gb3 synthase knockout.

Abstract
The ability of proximal tubule cells to internalize filtered proteins over a broad concentration range is essential for maintaining a protein-free urine but also renders these cells uniquely susceptible to cytotoxic damage. Morace et al. find that knockout of globotriaosylceramide synthase, an enzyme required for production of Gb3 and other members of the globo series of glycosphingolipids, impairs endocytic uptake of filtered proteins and preserves kidney function in mouse models of acute kidney injury.
AuthorsAnatália Labilloy, Ora A Weisz
JournalKidney international (Kidney Int) Vol. 96 Issue 2 Pg. 270-272 (08 2019) ISSN: 1523-1755 [Electronic] United States
PMID31331463 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Albumins
  • Trihexosylceramides
  • globotriaosylceramide
  • Galactosyltransferases
  • UDP-galactose-lactosylceramide alpha 1-4-galactosyltransferase
Topics
  • Acute Kidney Injury
  • Albumins
  • Animals
  • Galactosyltransferases
  • Mice
  • Trihexosylceramides

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