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Synthesis and in-vivo taste assessment of meloxicam pivalate.

Abstract
Meloxicam (MX), a nonsteroidal anti-inflammatory drug, widely used to treat arthritis, has a very bitter taste. Chemical modification of the bitter functionality was achieved by synthesis of a prodrug, meloxicam pivalate (MXP). Taste improvement was evaluated using single bottle-test rat model. It was found that palatability of MXP solution improved significantly as compared to MX.
AuthorsBandoo C Chatale, Mariam S Degani
JournalDrug development and industrial pharmacy (Drug Dev Ind Pharm) Vol. 45 Issue 10 Pg. 1590-1598 (Oct 2019) ISSN: 1520-5762 [Electronic] England
PMID31306048 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Prodrugs
  • Solutions
  • Meloxicam
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (chemistry)
  • Drug Delivery Systems (methods)
  • Male
  • Meloxicam (chemistry)
  • Prodrugs (chemistry)
  • Rats
  • Rats, Wistar
  • Solutions (chemistry)
  • Taste (drug effects)

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