Comparison of the Analgesic Effect of Intravenous Ketamine versus Intravenous Morphine in Reducing Pain of Renal Colic Patients: Double-Blind Clinical Trial Study.

Abstract

BACKGROUND:

The effective relief of renal colic patients with low complications is one of the important concerns of emergency physicians. The aim of this study was to investigate the use of injectable ketamine as an alternative to routine drugs in the relief of pain in patients with renal colic.

METHODS:

This double-blind clinical trial was conducted on patients who had suffered kidney pain due to kidney stones in 2017, referred to Ahvaz Imam Khomeini Hospital. Patients were divided into 2 groups: the first group received intravenous ketamine (0.3 mg/kg) and the second group received intravenous morphine (0.1 mg/kg) in a double-blind form. Finally, the mean pain was evaluated before injection, after 10, 20, 30, and 60 minutes as the initial result while the side effects were considered as secondary results.

RESULTS:

In this study, 135 patients with renal colic participate in this study. The mean pain at the time of referral to the hospital in the group receiving morphine and ketamine was 9.2 and 9.2, respectively, which did not show any significant difference. Based on these findings, there was no significant difference between the factors evaluated during the study of the two groups. Only in the ketamine group, there were 3 cases of nausea and 1 of vomiting. However, there was a significant increase in the need for additional doses of fentanyl in the morphine recipient group (p = 0.02).

CONCLUSION:

The findings suggest that the use of ketamine can produce a more rapid relief effect, and decrease the use of opioids which create various complications, including nausea and vomiting in patients, especially patients with renal colic.

• Authors: Arash Forouzan, Kambiz Masoumi, Hassan Motamed, Seyed Reza Naji Esfahani, Ali Delirrooyfard
• Journal: Reviews on recent clinical trials (Rev Recent Clin Trials) Vol. 14 Issue 4 Pg. 280-285 ( 2019) ISSN: 1876-1038 [Electronic] United Arab Emirates
• PMID: 31284871 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Analgesics, Opioid
• Anesthetics, Dissociative
• Ketamine
• Morphine

Topics

• Adult
• Analgesia (methods)
• Analgesics, Opioid (administration & dosage)
• Anesthetics, Dissociative (administration & dosage)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Female
• Follow-Up Studies
• Humans
• Infusions, Intravenous
• Ketamine (administration & dosage)
• Male
• Morphine (administration & dosage)
• Pain Measurement
• Renal Colic (diagnosis, drug therapy)
• Retrospective Studies
• Treatment Outcome