Assessment of the relationship between polysomnography parameters and plasma malondialdehyde levels in patients with obstructive sleep apnea.

Abstract

PURPOSE:

The relationship of plasma malondialdehyde (MDA) with major parameters of PSG was investigated to find out if there was a correlation between these variables.

METHODS:

Polysomnograms were done on a total of 37 adults who do not have a history of any systemic illness, smoking, and supplement use. Plasma MDA measurements and their relationship with PSG parameters were analyzed.

RESULTS:

The mean MDA concentrations in patients with lower AHI values were also lower than those in the patients with higher AHI (p < 0.001). Higher predominance of apnea in patients with similar AHI values, longer mean apnea durations, O2 saturation dips to < 90%, and higher ODI values predicted higher plasma MDA concentrations.

CONCLUSIONS:

Higher oxidative stress measurements predicted more severe clinical picture. These findings show that oxidative stress measurement with MDA may provide a simple tool to screen patients for OSA and help select them for PSG study appropriately, if indicated.

• Authors: Özden Savaş, Ahmet Emre Süslü, Incilay Lay, Serdar Özer
• Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 276 Issue 12 Pg. 3533-3538 (Dec 2019) ISSN: 1434-4726 [Electronic] Germany
• PMID: 31263978 (Publication Type: Journal Article)

Chemical References

• Malondialdehyde

Topics

• Adolescent
• Adult
• Aged
• Female
• Humans
• Male
• Malondialdehyde (blood)
• Middle Aged
• Oxidative Stress (physiology)
• Polysomnography (methods, statistics & numerical data)
• Predictive Value of Tests
• Sleep Apnea, Obstructive (blood, diagnosis, physiopathology)
• Turkey