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Haploidentical, Unmanipulated Granulocyte Colony-Stimulating Factor (G-CSF)-Primed Peripheral Blood Stem Cell Transplants for Acute Myeloid Leukemia (AML) in Remission: A Single Center Experience.

Abstract
BACKGROUND Data about application of related haploidentical allogeneic hematopoietic stem cell transplantation (haplo-HSCT) on patients with high-risk or intermediate-risk acute myeloid leukemia (AML) in the first complete remission (CR1) are lacking. In this study, we report the outcomes of using unmanipulated haploidentical allogeneic peripheral blood stem cell transplantation (haplo-PBSCT) as post-remission therapy for patients with high-risk or intermediate-risk AML in CR1. MATERIAL AND METHODS From January 2008 to July 2016, 33 patients diagnosed as high-risk or intermediate-risk AML in CR1 undergoing haplo-PBSCT in our institution were enrolled for analysis. The cumulative incidence of platelet and neutrophil recovery, the occurrence of acute graft-versus-host-disease (GVHD) and chronic GVHD, relapse and non-relapse mortality were assessed. Patients' survival rates were estimated using the Kaplan-Meier method. RESULTS The cumulative incidence of grade 2-4 acute GVHD, overall and extensive chronic GVHD was 18.2%, 9.1%, and 6.1%, respectively. 2-year probability of relapse was 9.1%. Disease-free survival and overall survival at 2 years were 72.7% and 75.8%, respectively. CONCLUSIONS Our results showed that unmanipulated haploidentical transplantation with G-CSF primed PBSC alone as a graft source could be an acceptable alternative post-remission treatment for high-risk or intermediate-risk AML patients in CR1 lacking a matched donor.
AuthorsLan Luo, Shu Fang, Shasha Zhao, Fei Li, Yu Zhou, Lixun Guan, Nan Yang, Zhenyang Gu, Tao Lin, Feiyan Wang, Chengying Zhu, Wenrong Huang, Daihong Liu, Chunji Gao
JournalAnnals of transplantation (Ann Transplant) Vol. 24 Pg. 367-373 (Jun 21 2019) ISSN: 2329-0358 [Electronic] United States
PMID31221952 (Publication Type: Journal Article)
Chemical References
  • Granulocyte Colony-Stimulating Factor
Topics
  • Adolescent
  • Adult
  • Female
  • Graft vs Host Disease (epidemiology, etiology)
  • Granulocyte Colony-Stimulating Factor (therapeutic use)
  • Humans
  • Incidence
  • Leukemia, Myeloid, Acute (mortality, surgery)
  • Male
  • Middle Aged
  • Peripheral Blood Stem Cell Transplantation (adverse effects, methods)
  • Survival Rate
  • Transplantation Conditioning (methods)
  • Young Adult

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