Abstract | BACKGROUND: METHODS: This systematic review protocol has been developed based on PRISMA-P guidelines for reporting systematic reviews evaluating health care interventions. We will include all published and unpublished randomized controlled trials (RCTs) comparing different antibiotics used for the treatment of OT. We will consider changes in visual acuity, number of recurrences, improvement or worsening of ocular inflammation, size of lesion, and adverse effects as our outcomes. Screening, data extraction, and quality assessment will be undertaken by two reviewers with disagreements resolved through discussion. Studies that compared antibiotics with placebo will be excluded. The reviews will be assessed for quality and relevance. We will assess the risk of bias in five domains according to Cochrane group's tool. The type of data will dictate measures of treatment effect. We will use a random-effects model to calculate our meta-analysis, as eligible studies represent clinically varied populations of participants. DISCUSSION: The strength of our study will lie in the exhaustive and systematic nature of the literature search, as well as in its methods for assessing quality and analyzing RCT data. Considering the controversial efficacy of the treatment for OT, our study will contribute to improving the existing evidence on the effectiveness of different antibiotics. Future studies may be conducted to increase physicians' awareness of antibiotic therapies, improving the health of patients with OT. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42018085468.
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Authors | John E Feliciano-Alfonso, Andrés Vargas-Villanueva, María Alejandra Marín, Laura Triviño, Natalia Carvajal, Manuela Moreno, Tatiana Luna, Clara Lopez de Mesa, Juliana Muñoz-Ortiz, Alejandra de-la-Torre |
Journal | Systematic reviews
(Syst Rev)
Vol. 8
Issue 1
Pg. 146
(06 20 2019)
ISSN: 2046-4053 [Electronic] England |
PMID | 31221217
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Antiprotozoal Agents
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Topics |
- Humans
- Anti-Bacterial Agents
(adverse effects, therapeutic use)
- Antiprotozoal Agents
(adverse effects, therapeutic use)
- Toxoplasma
(drug effects)
- Toxoplasmosis, Ocular
(drug therapy)
- Treatment Outcome
- Meta-Analysis as Topic
- Systematic Reviews as Topic
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