[Clinical Features and Therapeutic Efficacy in Adult Acute Lymphoblastic Leukemia with t (1; 19) (E2A-PBX1)].

Abstract

OBJECTIVE:

To explore the clinical features and therapeutic efficacy in adult ALL patients with t (1; 19) (E2A-PBX1).

METHODS:

The clinic data of 19 adult ALL patients with t (1; 19) (E2A-PBX1) in our hospital from Nov. 22, 2010 to Apr. 4, 2018 were collected. The clinical features,complete remission (CR) rate, overall survival (OS) rate and relapse-free survival (RFS) rate of patients received chemotherapy and chemotherapy+HSCT were analyzed.

RESULTS:

In all the 19 patients, the median age was 24 (14-66), median WBC count was 16.47×109 (1.8-170.34)/L, median Hb level was 98 (65-176) g/L, median Plt count was 50 (15-254)×109/L. Pre B-ALL were 17 cases (89.5%), and common B-ALL were 2 cases (10.5%). Patients received the induction therapy, the overall CR rate was 94.7%, one course CR rate was 94.7%, 4 year OS rate was 47.1% and RFS rate was 43.3%. The OS rate and RFS rate of patients received transplantation were slightly higher than those of patients not received transplantation (OS: 62.5% vs 36.7%) (P=0.188)；RFS (62.5% vs 38.9%) (P=0.166).

CONCLUSION:

Most adult ALL patients with t (1; 19) (E2A-PBX1) is Pre B-ALL by Immunophenotyping, as compared with the pediatric patients, the therapeutic efficacy for adult patients with t (1; 19) (E2A-PBX1) is worsen, therefore, stem cell transplantation is still acquired for better long term survival.

• Authors: Kai-Qi Liu, Xiao-Yuan Gong, Xing-Li Zhao, Hui Wei, Ying Wang, Dong Lin, Chun-Lin Zhou, Bing-Cheng Liu, Hui-Jun Wang, Cheng-Wen Li, Qing-Hua Li, Ben-Fa Gong, Yan Li, Yun-Tao Liu, Ying-Chang Mi, Jian-Xiang Wang
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 27 Issue 3 Pg. 637-640 (Jun 2019) ISSN: 1009-2137 [Print] China
• PMID: 31204910 (Publication Type: Journal Article)

Chemical References

• Homeodomain Proteins
• Oncogene Proteins, Fusion
• E2A-Pbx1 fusion protein

Topics

• Adult
• Chromosomes, Human, Pair 1
• Chromosomes, Human, Pair 19
• Homeodomain Proteins (genetics)
• Humans
• Immunophenotyping
• Oncogene Proteins, Fusion (genetics)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics, therapy)
• Recurrence
• Remission Induction