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A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B.

Abstract
Chronic infection by the hepatitis B virus (HBV) has remained a major public health problem. To achieve an HBV cure, we will likely need to combine antivirals with different viral targets as well as immunotherapy. Here, we report data from a pilot proof-of-concept clinical trial of nitazoxanide in treating chronic hepatitis B. Conclusion: Nitazoxanide offers novel mechanisms of antiviral activity, and it would be interesting to evaluate the potential of combining nitazoxanide with oral nucleos(t)ide analogues.
AuthorsJean-François Rossignol, Christian Bréchot
JournalHepatology communications (Hepatol Commun) Vol. 3 Issue 6 Pg. 744-747 (Jun 2019) ISSN: 2471-254X [Electronic] United States
PMID31168509 (Publication Type: Journal Article)

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