Abstract |
Mitofusin 2 (MFN2) tethers mitochondria to the endoplasmic reticulum (ER). In the 7 May 2019 issue of Science Signaling, Kuo et al. report that polycystin 2 (PC2), encoded by a gene mutated in type 2 autosomal dominant polycystic kidney disease ( ADPKD), contributes to cystogenesis by affecting MFN2, thus extending the role of mitochondria-ER contact sites to a common genetic disorder.
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Authors | Isotta Lorenzi, Luca Scorrano |
Journal | Science signaling
(Sci Signal)
Vol. 12
Issue 583
(05 28 2019)
ISSN: 1937-9145 [Electronic] United States |
PMID | 31138767
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review, Comment)
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Copyright | Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. |
Chemical References |
- TRPP Cation Channels
- polycystic kidney disease 2 protein
- Calcium
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Topics |
- Calcium
- Energy Metabolism
- Humans
- Polycystic Kidney, Autosomal Dominant
- TRPP Cation Channels
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