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Too close not to encyst: Polycystic kidney disease and interorganellar contact sites.

Abstract
Mitofusin 2 (MFN2) tethers mitochondria to the endoplasmic reticulum (ER). In the 7 May 2019 issue of Science Signaling, Kuo et al. report that polycystin 2 (PC2), encoded by a gene mutated in type 2 autosomal dominant polycystic kidney disease (ADPKD), contributes to cystogenesis by affecting MFN2, thus extending the role of mitochondria-ER contact sites to a common genetic disorder.
AuthorsIsotta Lorenzi, Luca Scorrano
JournalScience signaling (Sci Signal) Vol. 12 Issue 583 (05 28 2019) ISSN: 1937-9145 [Electronic] United States
PMID31138767 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review, Comment)
CopyrightCopyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Chemical References
  • TRPP Cation Channels
  • polycystic kidney disease 2 protein
  • Calcium
Topics
  • Calcium
  • Energy Metabolism
  • Humans
  • Polycystic Kidney, Autosomal Dominant
  • TRPP Cation Channels

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