A double-blind controlled crossover study to investigate the efficacy of salix extract on primary dysmenorrhea.

Abstract

OBJECTIVES:

Primary dysmenorrhea in the absence of pelvic pathology is a common gynecologic disorder affecting the quality of life of women of reproductive age. This study evaluates the effect of salix extract on primary dysmenorrhea.

DESIGN:

This study was a randomized crossover clinical trial.

SETTING:

The study population included 96 female students with level two or three of primary dysmenorrhea: 48 students in the treatment group (sequence I) followed by control (sequence II) and 48 students in control group (sequence I) followed by treatment (sequence II).

INTERVENTIONS:

The intervention was salix capsule (400 mg daily) and the active control was mefenamic acid capsule (750 mg daily) as.

MAIN OUTCOMES:

Pain intensity, measured by the visual analog scale (VAS), amount of bleeding, and severity of dysmenorrhea symptoms were outcomes. Generalized estimating equations were used for data analysis.

RESULTS:

The demographic and menstrual characteristics of the students were homogenous between the groups. The results showed that the students in mefenamic acid group had a significantly higher level of VAS than the students in the salix group over time (1.61 ± 0.06, P < 0.001). The estimated odds of the bleeding level in the salix and mefenamic acid group were not significantly different (P = 0.31). In average, 77.39%±16.18 of the students in salix group showed no symptoms followed by 22.18%±14.08 of the students who experienced mild symptoms. Averagely, 44.58%±20.16 of the students in the mefenamic acid group had mild symptoms followed by moderate symptoms (28.12%±15.29).

CONCLUSIONS:

Salix extract significantly decreased dysmenorrhea in comparison to mefenamic acid, as the standard treatment of dysmenorrhea.

• Authors: Z Raisi Dehkordi, M Rafieian-Kopaei, F S Hosseini-Baharanchi
• Journal: Complementary therapies in medicine (Complement Ther Med) Vol. 44 Pg. 102-109 (Jun 2019) ISSN: 1873-6963 [Electronic] Scotland
• PMID: 31126541 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2019 Elsevier Ltd. All rights reserved.

Chemical References

• Plant Extracts
• Mefenamic Acid

Topics

• Adult
• Cross-Over Studies
• Double-Blind Method
• Dysmenorrhea (drug therapy)
• Female
• Humans
• Mefenamic Acid (therapeutic use)
• Plant Extracts (therapeutic use)
• Quality of Life
• Salix (chemistry)
• Young Adult