Abstract | OBJECTIVES: In this study we aimed to investigate foetal and maternal pregnancy outcomes from a large multicentre cohort of women diagnosed with MCTD and anti-U1RNP antibodies. METHODS: This multicentre retrospective cohort study describes the outcomes of 203 pregnancies in 94 consecutive women ever pregnant who fulfilled the established criteria for MCTD with confirmed U1RNP positivity. RESULTS: CONCLUSION: In our multicentre cohort, women with MCTD had a live birth rate of 72%. While the true frequency of heart block associated with anti-U1RNP remains to be determined, this study might raise the consideration of echocardiographic surveillance in this setting. Pregnancy counselling should be considered in women with MCTD.
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Authors | Massimo Radin, Karen Schreiber, Maria José Cuadrado, Irene Cecchi, Laura Andreoli, Franco Franceschini, Teresa Caleiro, Danieli Andrade, Elena Gibbone, Munther Khamashta, Jill Buyon, Peter Izmirly, Maria Angeles Aguirre, Chiara Benedetto, Dario Roccatello, Luca Marozio, Savino Sciascia |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 58
Issue 11
Pg. 2000-2008
(11 01 2019)
ISSN: 1462-0332 [Electronic] England |
PMID | 31079145
(Publication Type: Journal Article, Multicenter Study)
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Copyright | © The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: [email protected]. |
Chemical References |
- Autoantibodies
- Ribonucleoprotein, U1 Small Nuclear
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Topics |
- Abortion, Spontaneous
(epidemiology, immunology)
- Adult
- Autoantibodies
(blood)
- Diabetes, Gestational
(epidemiology, immunology)
- Female
- Fetal Growth Retardation
(immunology)
- Heart Block
(congenital, immunology)
- Humans
- Hypertension, Pregnancy-Induced
(epidemiology, immunology)
- Infant, Newborn
- Live Birth
(epidemiology)
- Lupus Erythematosus, Systemic
(congenital, immunology)
- Mixed Connective Tissue Disease
(complications, immunology)
- Pregnancy
- Pregnancy Complications
(blood, immunology)
- Pregnancy Outcome
- Retrospective Studies
- Ribonucleoprotein, U1 Small Nuclear
(immunology)
- Stillbirth
(epidemiology)
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