Abstract | BACKGROUND: METHODS: Data from a total of 89,533 CKD patients comprising CKD diagnosis, dialysis, fracture history, and phosphate binder prescription history from 2012 to 2016 were retrieved from the Health Insurance Review and Assessment Service Database. Multivariate Cox regression analyses were performed to identify whether dialysis or phosphate binders were associated with an increased fracture risk. RESULTS: Overall, the rate of fractures in pre-dialysis CKD patients was 74 per 1,000 patient-years, while that in dialysis patients was 84 per 1,000 patient-years. The risk of fracture in ESRD patients was higher than pre-dialysis CKD patients (hazard ratio, 1.16; 95% confidence interval, 1.12-1.21; P < 0.001) after adjusting for confounding variables. In addition, the fracture risk in patients who were not taking phosphate binders was 20.0% higher compared to ESRD patients taking phosphate binders. CONCLUSION: Fractures were more prevalent in ESRD patients on dialysis than pre-dialysis CKD patients. Use of phosphate binders was associated with a lower fracture risk in ESRD patients.
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Authors | Young Eun Kwon, Hyung Yun Choi, Sol Kim, Dong-Ryeol Ryu, Hyung Jung Oh, ESRD Registry Committee of the Korean Society of Nephrology |
Journal | Kidney research and clinical practice
(Kidney Res Clin Pract)
Vol. 38
Issue 2
Pg. 220-228
(Jun 30 2019)
ISSN: 2211-9132 [Print] Korea (South) |
PMID | 31067609
(Publication Type: Journal Article)
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