Indigenously Prepared Ready-to-use Therapeutic Food (RUTF) in Children with Severe Acute Malnutrition.

Abstract

OBJECTIVE:

To compare efficacy of indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy) with Standard Nutrition Therapy in children with Severe acute malnutrition.

DESIGN:

Two facility-based and two community-based models: (i) Open prospective randomized controlled trial comparing Indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy) with Standard Nutrition Therapy; (ii) Only Indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy); (iii) Doorstep Child Care Centre; and (iv) Community-based Management of Acute Malnutrition.

SETTING:

(i) Urban Health Center, Dharavi, Mumbai; (ii) Two day care centers of Non-governmental Organization SNEHA - Mumbai; (iii) Urban slums, M East and L Ward, Mumbai.

PARTICIPANTS:

1105 children aged 6-60 months in community or hospital inpatient/ outpatient department diagnosed as Severe Acute Malnutrition by WHO definition.

INTERVENTION:

All subjects received either Indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy) or Standard Nutrition Therapy (protein calorie rich diet) for eight weeks and followed up for next four months.

MAIN OUTCOME MEASURES:

Mean rate of weight gain (g/kg/day), target weight, change in nutritional status.

RESULTS:

Rate of weight gain was higher (P<0.05) at 2 weeks on indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy) (5.63 g/kg/day) as compared to Standard Nutrition Therapy (3.43 g/kg/day). 61.2% subjects achieved target weight compared to 47.7% controls. At 8 weeks, 82.8% subjects recovered from Severe Acute Malnutrition compared to 19.3% controls (P<0.005). The results obtained in community were comparable to facility-based indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy). The morbidity was less in study group at follow-up.

CONCLUSIONS:

Indigenous Ready-to-use Therapeutic Food (Medical Nutrition Therapy) appeared to be superior to Standard Nutrition Therapy in promoting weight gain in children with Severe Acute Malnutrition.

• Authors: Alka Rajendra Jadhav, Prachi Karnik, Lavina Fernandes, Sneha Fernandes, Narendra Shah, Mamta Manglani
• Journal: Indian pediatrics (Indian Pediatr) Vol. 56 Issue 4 Pg. 287-293 (04 15 2019) ISSN: 0974-7559 [Electronic] India
• PMID: 31064896 (Publication Type: Journal Article, Randomized Controlled Trial)

Topics

• Child, Preschool
• Fast Foods
• Female
• Food, Formulated
• Humans
• Infant
• Male
• Nutritional Status
• Severe Acute Malnutrition (diet therapy, epidemiology)
• Weight Gain (physiology)