Abstract | Objective: Methods: After 14 minutes of untreated ventricular fibrillation, followed by 8 minutes of basic life support, 16 pigs randomly received either 80 mg/kg of pralidoxime ( pralidoxime group) or an equivalent volume of saline (control group) during advanced cardiovascular life support (ACLS). Results: Mixed-model analyses of left ventricular wall thickness and chamber area during ACLS revealed no significant group effects or group-time interactions, whereas a mixed-model analysis of the CPP during ACLS revealed a significant group effect (P=0.038) and group-time interaction (P<0.001). Post-hoc analyses revealed significant increases in CPP in the pralidoxime group, starting at 5 minutes after pralidoxime administration. No animal, except one in the pralidoxime group, achieved ROSC; thus, the rate of ROSC did not differ between the two groups. Conclusion:
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Authors | Yong Hun Jung, Dong Hyun Ryu, Kyung Woon Jeung, Joo-Young Na, Dong Hun Lee, Byung Kook Lee, Tag Heo, Yong Il Min |
Journal | Clinical and experimental emergency medicine
(Clin Exp Emerg Med)
Vol. 6
Issue 3
Pg. 204-211
(09 2019)
ISSN: 2383-4625 [Print] Korea (South) |
PMID | 31036784
(Publication Type: Journal Article)
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