Single-Needle Intensive Granulocyte and Monocyte Adsorptive Apheresis Is Suitable for Elderly Patients With Active Ulcerative Colitis Taking no Corticosteroids or Biologics.

Abstract

Twice-weekly intensive granulocyte/monocyte adsorptive apheresis is effective and safe for ulcerative colitis, but maintaining two blood access routes is problematic. We previously reported that intensive granulocyte/monocyte adsorptive apheresis using a single needle in ulcerative colitis is effective and safe. We hypothesized that the efficacy and safety of single-needle intensive granulocyte/monocyte adsorptive apheresis for ulcerative colitis would especially benefit the elderly. We enrolled 17 elderly ulcerative colitis patients to receive single-needle intensive granulocyte/monocyte adsorptive apheresis, 27 elderly ulcerative colitis patients to receive double-needle intensive granulocyte/monocyte adsorptive apheresis, and 52 nonelderly ulcerative colitis patients to receive single-needle intensive granulocyte/monocyte adsorptive apheresis. Remission and mucosal healing rates after treatment did not differ significantly between elderly ulcerative colitis patients receiving single-needle apheresis and the other two groups. In addition, no serious adverse effects, including blood clots, were observed in single-needle intensive granulocyte/monocyte adsorptive apheresis patients. Single-needle intensive granulocyte/monocyte adsorptive apheresis might be a novel alternative therapeutic option for elderly ulcerative colitis patients before considering corticosteroids.

• Authors: Takumi Fukuchi, Hideaki Koga, Shinji Kaichi, Akira Ishikawa, Takahisa Horita, Ryota Araki, Atsushi Yokota, Yukiomi Namba, Masahiro Kyo, Takaaki Eguchi, Keiji Shimazu
• Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (Ther Apher Dial) Vol. 23 Issue 3 Pg. 224-232 (Jun 2019) ISSN: 1744-9987 [Electronic] Australia
• PMID: 31025824 (Publication Type: Comparative Study, Journal Article)
• Copyright: © 2019 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.

Chemical References

• Adrenal Cortex Hormones
• Biological Products

Topics

• Adrenal Cortex Hormones
• Adsorption
• Aged
• Aged, 80 and over
• Biological Products
• Cohort Studies
• Colitis, Ulcerative (diagnosis, therapy)
• Female
• Geriatric Assessment
• Granulocytes (cytology)
• Humans
• Japan
• Leukapheresis (methods)
• Male
• Middle Aged
• Monocytes (cytology)
• Needles
• Patient Safety
• Severity of Illness Index
• Treatment Outcome