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Hypothermia in an Adolescent Due to Probable Drug-Drug Interaction Involving Clobazam.

Abstract
We report on a 16-year-old female who developed hypothermia as a result of a drug-drug interaction that produced supratherapeutic serum concentrations of clobazam. Although clobazam and its active metabolite (N-desmethylclobazam) are metabolized by cytochrome 2C19 (CYP2C19), literature suggests that clobazam-associated drug interactions involving this isoenzyme are not clinically relevant because of its wide therapeutic index. This report describes clobazam-associated hypothermia due to supratherapeutic serum concentrations of clobazam that resulted from the combination of 2 CYP2C19 inhibitors.
AuthorsMalinda G Parman, Amy P Holmes
JournalThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG (J Pediatr Pharmacol Ther) 2019 Mar-Apr Vol. 24 Issue 2 Pg. 156-159 ISSN: 1551-6776 [Print] United States
PMID31019409 (Publication Type: Case Reports)

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