Anti-Ro52 autoantibodies are associated with interstitial lung disease and more severe disease in patients with juvenile myositis.

Abstract

OBJECTIVES:

Anti-Ro52 autoantibodies are associated with more severe interstitial lung disease (ILD) in adult myositis patients with antiaminoacyl transfer (t)RNA synthetase autoantibodies. However, few studies have examined anti-Ro52 autoantibodies in juvenile myositis. The purpose of this study was to define the prevalence and clinical features associated with anti-Ro52 autoantibodies in a large cohort of patients with juvenile myositis.

METHODS:

We screened sera from 302 patients with juvenile dermatomyositis (JDM), 25 patients with juvenile polymyositis (JPM) and 44 patients with juvenile connective tissue disease-myositis overlap (JCTM) for anti-Ro52 autoantibodies by ELISA. Clinical characteristics were compared between myositis patients with and without anti-Ro52 autoantibodies.

RESULTS:

Anti-Ro52 autoantibodies were found in 14% patients with JDM, 12% with JPM and 18% with JCTM. Anti-Ro52 autoantibodies were more frequent in patients with antiaminoacyl tRNA synthetase (64%, p<0.001) and anti-MDA5 (31%, p<0.05) autoantibodies. After controlling for the presence of myositis-specific autoantibodies, anti-Ro52 autoantibodies were associated with the presence of ILD (36% vs 4%, p<0.001). Disease course was more frequently chronic, remission was less common, and an increased number of medications was received in anti-Ro52 positive patients.

CONCLUSIONS:

Anti-Ro52 autoantibodies are present in 14% of patients with juvenile myositis and are strongly associated with anti-MDA5 and antiaminoacyl tRNA synthetase autoantibodies. In all patients with juvenile myositis, those with anti-Ro52 autoantibodies were more likely to have ILD. Furthermore, patients with anti-Ro52 autoantibodies have more severe disease and a poorer prognosis.

• Authors: Sara Sabbagh, Iago Pinal-Fernandez, Takayuki Kishi, Ira N Targoff, Frederick W Miller, Lisa G Rider, Andrew Lee Mammen, Childhood Myositis Heterogeneity Collaborative Study Group
• Journal: Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 78 Issue 7 Pg. 988-995 (07 2019) ISSN: 1468-2060 [Electronic] England
• PMID: 31018961 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)
• Copyright: © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Chemical References

• Autoantibodies
• Ribonucleoproteins
• SS-A antigen

Topics

• Autoantibodies (blood, immunology)
• Child
• Dermatomyositis (blood, immunology)
• Female
• Humans
• Lung Diseases, Interstitial (epidemiology, immunology)
• Male
• Myositis (blood, immunology)
• Prevalence
• Ribonucleoproteins (immunology)