Low-Intensity Pulsed Ultrasound Prevents Development of Bisphosphonate-Related Osteonecrosis of the Jaw-Like Pathophysiology in a Rat Model.
|
| Abstract |
We developed a rat model of bisphosphonate-related osteonecrosis of the jaw (BRONJ) by removing a maxillary molar tooth (M1) from ovariectomized rats after treatment with alendronate. To mimic periodontitis, some of the rats were administered Porphyromonas gingivalis (p. gingivalis) at the M1 site every 2 to 3 d for 2 wk. Rats pretreated with alendronate plus p. gingivalis showed delayed healing of socket epithelia, periosteal reaction of alveolar bone formation and lower bone mineral density in the alveolus above adjacent M2 teeth. These abnormalities were prevented by tooth socket exposure to 20 min/d low-intensity pulsed ultrasound (LIPUS), which restored diminished expression of RANKL, Bcl-2, IL-6, Hsp70, NF-κB and TNF-α messenger ribonucleic acids in remote bone marrow, suggesting LIPUS prevented development of BRONJ-like pathophysiology in rat by inducing systemic responses for regeneration, in addition to accelerating local healing. Non-invasive treatment by LIPUS, as well as low-level laser therapy, may be useful for medication-related osteonecrosis of the jaw patients.
|
|---|---|
| Authors | Kouki Hidaka, Yuko Mikuni-Takagaki, Satoko Wada-Takahashi, Makiko Saita, Ryota Kawamata, Takenori Sato, Akira Kawata, Chihiro Miyamoto, Yojiro Maehata, Hirotaka Watabe, Nobuyuki Tani-Ishii, Nobushiro Hamada, Shun-Suke Takahashi, Shinji Deguchi, Ryohei Takeuchi |
| Journal | Ultrasound in medicine & biology (Ultrasound Med Biol) Vol. 45 Issue 7 Pg. 1721-1732 (07 2019) ISSN: 1879-291X [Electronic] England |
| PMID | 31006496 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright © 2019 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved. |
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!