Abstract |
Current factor VIII products expose recipients to many donors and hence to a high risk of acquiring blood-borne infections. Plasma-exchange donation of cryoprecipitate can reduce donor exposure by repeatedly obtaining large yields of factor VIII from individual donors. In this study, donor factor VIII levels were stimulated with desmopressin before donation. Mean yield per donation increased from 1399 +/- 425 IU in controls to 3818 +/- 1350 IU in stimulated donations (p less than 0.001), and mean factor VIII concentration in the cryoprecipitate increased from 8.2 +/- 3 IU/mL to 24 +/- 12 IU/mL (p less than 0.001). A new packaging system dispenses assayed aliquots of stimulated cryoprecipitate in plastic vials. The direct cost of production for this material is $.065 per unit. The cryoprecipitate is hemostatically active and convenient to use, and the aggregate yields from sequential donations by stimulated persons are high enough to allow long-term, single-donor support of many adults with hemophilia.
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Authors | B C McLeod, R J Sassetti, E R Cole, J P Scott |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 106
Issue 1
Pg. 35-40
(Jan 1987)
ISSN: 0003-4819 [Print] United States |
PMID | 3098152
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Factor VIII
- Deamino Arginine Vasopressin
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Topics |
- Blood Component Removal
(economics, methods)
- Chemical Precipitation
- Costs and Cost Analysis
- Deamino Arginine Vasopressin
(pharmacology)
- Drug Packaging
(economics)
- Factor VIII
(analysis, therapeutic use)
- Hemophilia A
(therapy)
- Humans
- Plasma Exchange
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