Abstract | PURPOSE: METHOD: Male Balb/c mice were pretreated with AMB (30, 70, and 100 mg/kg) once a day for 3 consecutive days before HC induction with CYP (300 mg/kg). Mesna (30 mg/kg;i.p.), only drug in the management of CYP-induced HC, was administered 20 min before; 4 and 8 h after cystitis induction. The urinary bladders were harvested and evaluated in functional, biochemical, and histological studies. RESULTS: CYP-induced HC markedly reduced acetylcholine (ACh)-induced contractions in detrusor strips and AMB at 100 mg/kg caused a significant increase in the responsiveness to ACh. Pretreatment with AMB prevented the elevation of malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) level, reduction of total glutathione (GSH) that induced by CYP. However, treatment with AMB did not improve the bladder weight and some histological parameters. CONCLUSION: These results suggest that AMB pretreatment could improve CYP-induced HC via antioxidant and antiinflammatory activities.
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Authors | Elif Nur Barut, Seckin Engin, Burak Barut, Cansu Kaya, Gokcen Kerimoglu, Arzu Ozel, Mine Kadioglu |
Journal | International urology and nephrology
(Int Urol Nephrol)
Vol. 51
Issue 5
Pg. 803-810
(May 2019)
ISSN: 1573-2584 [Electronic] Netherlands |
PMID | 30895504
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents, Alkylating
- Ambroxol
- Cyclophosphamide
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Topics |
- Ambroxol
(therapeutic use)
- Animals
- Antineoplastic Agents, Alkylating
(adverse effects)
- Cyclophosphamide
(adverse effects)
- Cystitis
(chemically induced, prevention & control)
- Hemorrhage
(chemically induced, prevention & control)
- Male
- Mice
- Mice, Inbred BALB C
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