Abstract | BACKGROUND: Myocardial protection in Tetralogy of Fallot patients undergoing intracardiac repair is suboptimal due to hypertrophied right ventricle. Hypertrophied myocardium is more susceptible to poor myocardial preservation because of inadequate capillary density as compared to the myocytes. There is a capillary to myocyte ratio mismatch. But del Nido Cardioplegia owing to its less viscosity is able to get more evenly distributed under hypothermic cardiopulmonary bypass as opposed to blood Cardioplegia. We hypothesized that the del Nido Cardioplegia technique, would be beneficial in myocardial protection because of its composition and method of delivery, leading into better early and late clinical outcomes in patients undergoing Tetralogy of Fallot repair as compared to blood cardioplegia reconstituted using St Thomas Cardioplegia solution. The objective of the study was to identify a better technique of myocardial preservation in Tetralogy of Fallot patient. METHODS: RESULTS: Inotropic score in the first 24 hours postoperatively was significantly lower in Group II compared to Group I (13.4 ± 7.2 vs. 21.2 ± 9.6, p = 0.003). Creatine kinase MB level (ng/mL) was comparable between the groups. Echocardiographic parameters for right ventricle functions were also comparable between the groups during early as well as after 3 to 6 months postoperatively. CONCLUSION:
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Authors | Sunder Lal Negi, Banashree Mandal, Rana Sandeep Singh, Goverdhan Dutt Puri |
Journal | Perfusion
(Perfusion)
Vol. 34
Issue 6
Pg. 495-502
(09 2019)
ISSN: 1477-111X [Electronic] England |
PMID | 30848697
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adolescent
- Cardioplegic Solutions
(administration & dosage)
- Cardiopulmonary Bypass
- Child
- Child, Preschool
- Female
- Heart Arrest, Induced
- Humans
- Infant
- Infant, Newborn
- Male
- Tetralogy of Fallot
(blood, physiopathology, surgery)
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