Chemotherapy-induced skin toxicity and capillary leak syndrome.

Abstract

BACKGROUND:

The occurrence of chemotherapy-related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS.

METHODS:

Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS.

RESULTS:

Five patients were identified, two with a diagnosis of toxic erythema of chemotherapy (TEC) and three others with a skin diagnosis of toxic epidermal necrolysis (TEN). Pathology of all patients was available for clinical-pathologic confirmation.

CONCLUSIONS:

Although TEC is generally self-limited, both TEC and TEN can present with severe adverse skin manifestations during CLS secondary to toxicity from chemotherapy.

• Authors: Manrup K Hunjan, Somaira Nowsheen, Alvaro J Ramos-Rodriguez, Alina G Bridges, Julia S Lehman, Shahrukh K Hashmi, Rokea A El-Azhary
• Journal: International journal of dermatology (Int J Dermatol) Vol. 58 Issue 7 Pg. 856-860 (Jul 2019) ISSN: 1365-4632 [Electronic] England
• PMID: 30847892 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2019 The International Society of Dermatology.

Chemical References

• Cytarabine
• Clofarabine

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Capillary Leak Syndrome (etiology)
• Clofarabine (adverse effects)
• Cytarabine (adverse effects)
• Erythema (chemically induced, complications, pathology)
• Female
• Humans
• Leukemia (drug therapy)
• Male
• Middle Aged
• Skin (drug effects, pathology)
• Stevens-Johnson Syndrome (complications, pathology)