Tissue-engineered solution containing cells and biomaterials-an in vitro study: A perspective as a novel therapeutic application.

Abstract

Some biomaterial scaffolds can positively interfere with tissue regeneration and are being developed to successfully repair the tissue function. The possibility of using epithelial cells combined with biomaterials appears to be a new option as therapeutic application. This combination emerges as a possibility for patients with Mayer-Rokitansky-Kuster-Hauser syndrome which requires vaginal repair and can be performed with tissue-engineered solution containing cells and biomaterials. It is expected that tissue-engineered solution containing cells and biomaterials would promote tissue repair in a more efficient, modern, and safe way. This study tested the efficiency of tissue-engineered solution containing human malignant melanoma cell line (HMV-II) and different biomaterials, including Cellprene®, Membracel®, and poly lactic-co-glycolic acid/epoxidized polyisoprene. The cells adhered better on poly lactic-co-glycolic acid/epoxidized polyisoprene, and it was found that tissue-engineered solution may also contain mesenchymal stem cells cultivated on poly lactic-co-glycolic acid/epoxidized polyisoprene. Histological, immunofluorescence, and scanning electron microscopy analyses were performed. These initial in vitro results suggest that tissue-engineered solution containing cells and poly lactic-co-glycolic acid/epoxidized polyisoprene is a potential for tissue reconstruction.

• Authors: Nicole Andréa Corbellini Henckes, Jaquelline Christine Dias Festa, Dalana Faleiro, Helouise Richardt Medeiros, Nayrim Brizuela Guerra, Luis Alberto Loureiro Dos Santos, Paula Barros Terraciano, Eduardo Pandolfi Passos, Fernanda Dos Santos de Oliveira, Elizabeth Obino Cirne-Lima
• Journal: The International journal of artificial organs (Int J Artif Organs) Vol. 42 Issue 6 Pg. 307-314 (Jun 2019) ISSN: 1724-6040 [Electronic] United States
• PMID: 30838938 (Publication Type: Journal Article)

Chemical References

• Biocompatible Materials
• Solutions
• Polylactic Acid-Polyglycolic Acid Copolymer

Topics

• 46, XX Disorders of Sex Development (surgery)
• Animals
• Biocompatible Materials (chemistry, pharmacology)
• Cell Line
• Congenital Abnormalities (surgery)
• Epithelial Cells
• Female
• Guided Tissue Regeneration (methods)
• Humans
• Mesenchymal Stem Cells
• Mullerian Ducts (abnormalities, surgery)
• Polylactic Acid-Polyglycolic Acid Copolymer (chemistry, pharmacology)
• Plastic Surgery Procedures (methods)
• Solutions
• Tissue Engineering (methods)
• Tissue Scaffolds