New therapy with XLQ® to suppress chronic prostatitis through its anti-inflammatory and antioxidative activities.

Abstract

Chronic prostatitis is a common urological disease. The etiology of this disease and effective therapy for its treatment are yet to be elucidated. We investigated the functions of XLQ® in chronic nonbacterial prostatitis using a complete Freund's adjuvant-induced rat model. Prostates and blood samples were collected for further evaluation after oral gavage with XLQ ® or a vehicle for 4 weeks. The results showed that XLQ ® significantly decreased the prostate index, ameliorated the histopathologic changes, and reduced CD3+ and CD45+ cell infiltration in the prostate stroma. Further study showed that XLQ ® suppressed the expression of proinflammatory cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17A, monocyte chemoattractant protein-1, and tumor necrosis factor-α. XLQ ® showed a strong antioxidant capacity by enhancing the activities of antioxidative enzymes (e.g., total superoxide dismutase, catalase, and glutathione peroxidase) and decreasing the level of lipid peroxidation products (malondialdehyde). Moreover, XLQ ® can suppress the activation of nuclear factor-κB and P38-mitogen-activated protein kinase signaling pathways. In summary, XLQ ® has affirmative effects on chronic prostatitis, which could be attributed to its anti-inflammatory and antioxidative capacities. On the basis of these results, XLQ ® can be developed as an effective and safe therapy for chronic prostatitis.

• Authors: Feiya Yang, Lingquan Meng, Panpan Han, Dexi Chen, Mingshuai Wang, Yongguang Jiang, Yanqiao Wu, Yiling Wu, Nianzeng Xing
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 234 Issue 10 Pg. 17570-17577 (08 2019) ISSN: 1097-4652 [Electronic] United States
• PMID: 30790289 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 Wiley Periodicals, Inc.

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Cytokines
• Drugs, Chinese Herbal
• Rela protein, rat
• Transcription Factor RelA
• p38 Mitogen-Activated Protein Kinases

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Antioxidants (therapeutic use)
• Chronic Disease
• Cytokines (metabolism)
• Disease Models, Animal
• Down-Regulation (drug effects)
• Drugs, Chinese Herbal (therapeutic use)
• Humans
• Leukocytes (drug effects, immunology, pathology)
• Male
• Oxidative Stress (drug effects)
• Phytotherapy
• Prostatitis (drug therapy, immunology, metabolism)
• Rats
• Rats, Sprague-Dawley
• Signal Transduction (drug effects)
• T-Lymphocytes (drug effects, immunology, pathology)
• Transcription Factor RelA (metabolism)
• p38 Mitogen-Activated Protein Kinases (metabolism)